Translocation 21q22q in an infertile human male.
نویسندگان
چکیده
منابع مشابه
Molecular Dissection Using Array Comparative Genomic Hybridization and Clinical Evaluation of An Infertile Male Carrier of An Unbalanced Y;21 Translocation: A Case Report and Review of The Literature
Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated wi...
متن کاملSegregation analysis of a large t(21q22q) family.
A large family in which a t(21q22q) chromosome is segregating is described. Segregation analysis using data from this family and previously published families shows the risk to a female carrier of having a child with transloca-tion Down's syndrome to be O-0684 + 0'0270. The risk to a male carrier is probably much smaller with an upper limit of 0-0286. The segregation ratio for phenotypically no...
متن کاملChromosomal Translocation t (10;19) (q11.2;q13.4) in an Infertile Male.
Chromosomal rearrangements are usually associated with male factor infertility. We report here a 34-year-old man suffering from primary infertility for 15 years. The cytogenetic analysis and investigation of Y-chromosome microdeletions were performed. A reciprocal balanced translocation t (10;19) (q11.2;q13.4) was found in oligozoospermic infertile men with no Y-chromosome microdeletions. In th...
متن کاملCytogenetic determinants of male fertility
BACKGROUND Cytogenetic abnormalities have been known to be important causes of male infertility for decades. METHODS Research publications from 1978 to 2008, from PubMed, have been reviewed. RESULTS These studies have greatly improved our information on somatic chromosomal abnormalities such as translocations, inversions and sex chromosomal anomalies, and their consequences to the cytogenet...
متن کاملO-4: Association of Y Chromosome Microdeletion with Spermatogenic Impairment and Infertility in Human Males with High Concentration of Seminal Hexachlorocyclohexane (HC)
Background: The Y chromosome microdeletion is one of the best-documented causes of male infertility but the factors responsible for Y chromosome microdeletions in spermatozoa remain unresolved. However, the environmental pollutants are known to damage DNA in differentiating and maturing germ cells in the male reproductive tract. In view of this, the objective of the present study was to explore...
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عنوان ژورنال:
- Journal of medical genetics
دوره 19 5 شماره
صفحات -
تاریخ انتشار 1982